̂− production is the activity of glycerol 3-phosphate dehydrogenase (G3PDH).In insects, an additional mechanism involved in mitochondrial O 2 ̂−radicals are generated within the mitochondrial matrix, at the intermembrane space and the outer membrane, which are then dismutated to H 2O 2 by superoxide dismutases.̂−) radicals and to hydrogen peroxide (H 2O 2), , which diffuses through the cell playing both signaling and harmful roles.
A small portion of the oxygen consumed by mitochondria is partially reduced to superoxide (O 2 Mitochondria are organelles involved not only on aerobic energy transduction from nutrient oxidation to allow ATP synthesis through the oxidative phosphorylation, but also in redox balance, representing one of the major sources of cellular reactive oxygen species (ROS). PLO, AG, MAVS, MHFS and MFO are research scholars from CNPq.Ĭompeting interests: The authors have declared that no competing interests exist. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: This work was supported by grants from Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) (through Institutos Nacionais de Ciência e Tecnologia 2008), Fundação Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ) (MFO through Jovens Cientistas do Nosso Estado 2007), International Centre for Genetic Engineering and Biotechnology (ICGEB), World Health Organization-Tropical Disease Research (WHO-TDR-SSI, A60265), and Howard Hughes Medical Institute (HHMI). Received: ApAccepted: OctoPublished: November 16, 2009Ĭopyright: © 2009 Goncalves et al. PLoS ONE 4(11):Įditor: Marcelo Hermes-Lima, Universidade de Brasília, Brazil (2009) Blood-Feeding Induces Reversible Functional Changes in Flight Muscle Mitochondria of Aedes aegypti Mosquito. Citation: Gonçalves RLS, Machado ACL, Paiva-Silva GO, Sorgine MHF, Momoli MM, Oliveira JHM, et al.
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